"MDM2" Related Products

Expand
Expand
Expand

Recombinant Human MDM2

Cat.No.: MDM2-2319H
Product Overview: Recombinant Human MDM2 was expressed in E. coli.
Description: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Source: E. coli
Species: Human
Form: 50 mM Hepes pH 8.0, 200 mM NaCl, 10% glycerol, 5 mM TCEP
Bio-activity: Recombinant Human Mdm2/Hdm2 is a RING finger Ubiquitin ligase (E3) that functions downstream of a Ubiquitin-activating (E1) enzyme and a Ubiquitin-conjugating (E2) enzyme to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human Mdm2/Hdm2 concentration of 0.5-5 µM.
Molecular Mass: 55 kDa
Purity: >85%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -70 ºC as supplied.3 months, -70 ºC under sterile conditions after opening.
Gene Name: MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens (human) ]
Official Symbol: MDM2
Synonyms: MDM2; MDM2 proto-oncogene, E3 ubiquitin protein ligase; HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; double minute 2, human homolog of; p53-binding protein; oncoprotein Mdm2
Gene ID: 4193
mRNA Refseq: NM_001145337
Protein Refseq: NP_001138809
MIM: 164785
UniProt ID: Q00987
Chromosome Location: 12q14.3-q15
Pathway: AKT phosphorylates targets in the cytosol; Adaptive Immune System; Cellular Senescence
Function: enzyme binding; identical protein binding; ligase activity; p53 binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.