Recombinant Human CTH, MYC/DDK-tagged

• Cat.No.: CTH-1335H
• Product Overview: Recombinant Human CTH, transcript variant 1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 44.3 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: CTH cystathionine gamma-lyase [ Homo sapiens (human) ]
• Official Symbol: CTH
• Synonyms: CTH; cystathionase (cystathionine gamma-lyase); MGC9471; cystathionine gamma-lyase; OTTHUMP00000010945; OTTHUMP00000010946; gamma-cystathionase; homoserine deaminase; cysteine desulfhydrase; homoserine dehydratase; EC 4.4.1.1
• Gene ID: 1491
• mRNA Refseq: NM_001902
• Protein Refseq: NP_001893
• MIM: 607657
• UniProt ID: P32929
• Chromosome Location: 1p31.1
• Pathway: Cysteine and methionine metabolism; Glycine; L-cysteine degradation II; Metabolic pathways; Nitrogen metabolism; Selenium Pathway; Selenocompound metabolism
• Function: L-cysteine desulfhydrase activity; cystathionine beta-lyase activity; cystathionine gamma-lyase activity; lyase activity; pyridoxal phosphate binding