Recombinant Human GH1 therapeutic protein

• Cat.No.: GH-P016H
• Product Overview: ecombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli

Specification

• Description: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. The expression product is the active ingredient of BioTropin, Genotropin, Humatrope, Norditropin, Nutropin, NutropinAQ, Protropin, Saizen, Serostim and Tev-Tropin.
• Source: E. coli
• Species: Human
• Molecular Mass: 22.1 KDa
• Protein length: 191 Aa
• AA Sequence: FPTIPLSRLFDNAMLRAHRLHQLAF DTYQEFEEAYIPKEQKYSFLQNPQT SLCFSESIPTPSNREETQQKS NLELLRISLLLIQSWLEPVQFLRSV FANSLVYGASDSNVYDLLKDLEEGI QTLMGRLEDGSPRTGQIFKQT YSKFDTNSHNDDALLKNYGLLYCFR KDMDKVETFLRIVQCRSVEGSCGF
• Endotoxin: < 1.0 EU per μg of the protein
• Purity: >95%
• Storage: Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles.

Gene Information

• Gene Name: GH1 growth hormone 1 [ Homo sapiens ]
• Official Symbol: GH1
• Synonyms: GH1; growth hormone 1; somatotropin; GH; GH N; GHN; hGH N; pituitary growth hormone; GH-N; hGH-N; IGHD1B
• Gene ID: 2688
• mRNA Refseq: NM_000515
• Protein Refseq: NP_000506
• MIM: 139250
• UniProt ID: P01241
• Chromosome Location: 17q22-q24
• Pathway: Adipogenesis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem
• Function: growth factor activity; growth hormone receptor binding; growth hormone receptor binding; hormone activity; metal ion binding; prolactin receptor binding; protein binding