Recombinant HER2/neu (478-584)
Cat.No. : | ERBB2-01 |
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Source : | E.coli |
Form : | 20mM Tris-HCl, pH8.0, 200mM NaCl |
Molecular Mass : | (Theoretical molecular weight): ~12kDa |
AA Sequence : | LCFVHTVPWDQLFRNPHQALLHSGN RPEEDCGLEGLVCNSLCAHGHCWGP GPTQCVNCSH FLRGQECVEECRVWKGLPREYVSDK RCLPCHPECQPQNSSETCFGSE |
Purity : | >92% as determined by SDS-PAGE |
Storage : | Short Term Storage +4°C. Long Term Storage -20°C. Prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Gene Name : | erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog [ Xenopus laevis ] |
Official Symbol : | ERBB2 |
Synonyms : | ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; receptor tyrosine kinase ErbB2; |
Gene ID : | 724075 |
mRNA Refseq : | NM_001095593 |
Protein Refseq : | NP_001089062 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; Focal adhesion, organism-specific biosystem; |
Products Types
◆ Lysates | ||
ERBB2-2008RCL | Recombinant Rhesus ERBB2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a question1.Prepare the streptavidin-coated plate by washing it with PBS (phosphate-buffered saline) or another suitable buffer to remove any impurities. 2.Dilute the Avi-tagged protein in the desired buffer at the desired concentration. It is important to use a buffer that is compatible with the protein and does not interfere with its activity or stability. 3.Add the diluted protein to the streptavidin-coated plate and incubate it for a suitable amount of time at room temperature or 4°C. The exact conditions will depend on the specific protein and the desired level of immobilization. 4.Wash the plate with a suitable buffer to remove any unbound protein. 5.Block the remaining binding sites on the plate with a suitable blocking agent such as BSA (bovine serum albumin) or casein. 6.Wash the plate again to remove any unbound blocking agent. 7.Use the immobilized protein for further experiments such as ELISA, Western blotting, or other assays.
ERBB2 is a receptor tyrosine kinase involved in the regulation of cell growth and differentiation.
Therapeutic agents targeting ERBB2 include trastuzumab and lapatinib.
ERBB2 is commonly overexpressed in breast, ovarian, and stomach cancers.
ERBB2 overexpression is often associated with aggressive disease and poor prognosis.
ERBB2 levels can be assessed using immunohistochemistry and fluorescence in situ hybridization (FISH) in tissue samples.
It forms heterodimers with other ERBB receptors, activating pathways that promote cell growth and survival.
Amplification of the ERBB2 gene leads to its overexpression in cancer cells.
Customer Reviews (3)
Write a reviewWorked as expected, satisfied.
Reliable in protein assays.
Quick and reliable shipping.
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