Recombinant Marmoset TFRC Protein, His-tagged

• Cat.No.: Tfrc-01M
• Product Overview: Recombinant Marmoset TFRC Protein With His tag was expressed in HEK293.

Specification

• Description: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
• Source: HEK293
• Species: Marmoset
• Tag: His
• Molecular Mass: 76.5 kDa
• AA Sequence: GYCKHVEPKIECQRLAGTESPAVEN PEENLPVVPQLYWDDLKKMLSEKLD TTDFTSTIKLLNENSYVPREAGSQK DENLAWYIENQFRECKLSKVWRDEH FVKIQVKDSAQNSVTITGTNSEFVY LVENPGGYVAYSQNATVTGKLVHAN FGTEKDFEDLDSPVNGSIVIVRAGK ITFAEKVANAESANAIGVLIYMDKT KFPIVDADVSFFGHAHLGTGDPYTP GFPSFNHTQFPPSRSSGLPNIPVQT ISRAAAERLFENMEGDCPSDWKTDS SCRMVTSQNKSVKLSVSNVMKEIKI LNIFGVIKGFVEPDRYVVVGAQRDS WGPGAAKSSVGTALLLELAQTFSDM VLKDGFQPSRSIVFASWSAGDFGSV GATEWLEGYLSSLHLKAFTFINLDK AVLGTSNFRVSASPLLYALIEKTMQ EVKHPVTGLSLYQDSNWASKVEKLT FDNAAFPFLAYSGIPAVSFCFCEDT DYPYLGTTMDTYKELIEKIPQLNKV ARAAAEVAGQFMIKLTHDVELNLDY ERYNSQLLSFLRNLNQYRADIREMG LSLQWLYSARGDFFRATSRLTTDFK NSEKTDRFVMKELNDRVMKVEYYFL SPYVSPRESPFRHIFWGSGSHTLSA LLEHLKLRKTNNRAFNETLFRNQLA LATWTIQGAANALSGDIWDIDNEFH HHHHH
• Purity: > 90% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 1.54 mg/mL
• Storage Buffer: PBS, pH 7.4

Gene Information

• Gene Name: TFRC transferrin receptor [ Callithrix jacchus (white-tufted-ear marmoset) ]
• Official Symbol: TFRC
• Synonyms: TFRC; transferrin receptor; transferrin receptor protein 1; transferrin receptor (p90, CD71); transferrin receptor 1
• Gene ID: 100407510
• mRNA Refseq: NM_001301847
• Protein Refseq: NP_001288776
• UniProt ID: H9BFK5