"FGFR4" Related Products

Expand
Expand

Recombinant Human FGFR4, MYC/DDK-tagged

Cat.No.: FGFR4-32H
Product Overview: Recombinant Human FGFR4, transcript variant 2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Source: HEK293 cells
Species: Human
Tag: MYC/DDK
Molecular Mass: 80.9 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens (human) ]
Official Symbol: FGFR4
Synonyms: FGFR4; fibroblast growth factor receptor 4; TKF; JTK2; CD334; MGC20292; OTTHUMP00000161430; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; EC 2.7.10.1; FGFR-4; CD334 antigen
Gene ID: 2264
mRNA Refseq: NM_022963
Protein Refseq: NP_075252
MIM: 134935
UniProt ID: P22455
Chromosome Location: 5q35.2
Pathway: Adaptive Immune System; DAP12 interactions; Downstream signal transduction
Function: ATP binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.