Recombinant Human ASRGL1 therapeutic protein

• Cat.No.: ASRGL1-P040H
• Product Overview: Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life. It is a modified enzyme used as an antineoplastic agent. It is a form of L-asparaginase which has undergone PEGylation. It is used in the treatment of acute lymphoblastic leukemia.

Specification

• Description: Recombinant Human L-asparaginase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.
• Source: E. coli
• Species: Human
• Molecular Mass: 31.7 kDa
• AA Sequence: MEFFKKTALAALVMGFSGAALALPN ITILATGGTIAGGGDSATKSNYTVG KVGVENLVNAVPQLKDIANVK GEQVVNIGSQDMNDNVWLTLAKKIN TDCDKTDGFVITHGTDTMEETAYFL DLTVKCDKPVVMVGAMRPSTS MSADGPFNLYNAVVTAADKASANRG VLVVMNDTVLDGRDVTKTNTTDVAT FKSVNYGPLGYIHNGKIDYQR TPARKHTSDTPFDVSKLNELPKVGI VYNYANASDLPAKALVDAGYDGIVS AGVGNGNLYKSVFDTLATAAK TGTAVVRSSRVPTGATTQDAEVDDA KYGFVASGTLNPQKARVLLQLALTQ TKDPQQIQQIFNQY
• Endotoxin: < 0.1 EU per μg of the protein
• Purity: >95%

Gene Information

• Gene Name: ASRGL1 asparaginase like 1 [ Homo sapiens ]
• Official Symbol: ASRGL1
• Synonyms: ALP; ALP1; CRASH; L-asparaginase; L-asparagine amidohydrolase; asparaginase-like 1 protein; asparaginase-like protein 1; beta-aspartyl-peptidase; isoaspartyl dipeptidase; testis secretory sperm-binding protein Li 242mP
• Gene ID: 80150
• mRNA Refseq: NM_001083926
• Protein Refseq: NP_001077395
• MIM: 609212
• UniProt ID: Q7L266
• Chromosome Location: 11q12.3
• Pathway: Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem
• Function: NOT N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; asparaginase activity; beta-aspartyl-peptidase activity