Recombinant Human AGR2, His-tagged
Cat.No. : | AGR2-63H |
Product Overview : | Recombinant Human Anterior Gradient Homolog 2 fused to His-tag on N-terminal produced inE.Coliis a single, non-glycosylated polypeptide chain containing 192 amino acids (21-175) & having a molecular mass of 22 kDa. |
- Specification
- Gene Information
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Cat. No. : | AGR2-63H |
Description : | AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor. |
Source : | Escherichia Coli. |
Sequence : | MRGSHHHHHHGMASMTGGQQMGRDL YDDDDKDRWGSMRDTTVKPGAKKDK DSRPKLPQTLSRGWGDQLIWTQTYE EALYKSKTSNKPLMIIHHLDECPHS QAL KKVFAENKEIQKLAEQFVLLNLVYE TTDKHLSPDGQ YVPRIMFVDPSLTVRADITGRYSNR LYAYE PADTALLLDNMKKALKLLKTEL |
Physical Appearance : | Sterile filtered clorless solution. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | The protein (1mg/ml) contains 1X PBS pH-7.4 |
Applications : | • ELISA • MS • Inhibition Assays • Western Blotting |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles |
Gene Name : | anterior gradient homolog 2 (Xenopus laevis) [ Homo sapiens ] |
Synonyms : | AG2; GOB-4; HAG-2; XAG-2; PDIA17; AGR2; anterior gradient 2 homolog; secreted cement gland homolog; protein disulfide isomerase family A, member 17; Anterior gradient protein 2 homolog; hAG-2; AG-2; Secreted cement gland protein XAG-2 homolog; HPC8; UNQ515/PRO1030 |
Gene ID : | 10551 |
mRNA Refseq : | NM_006408 |
Protein Refseq : | NP_006399 |
MIM : | 606358 |
UniProt ID : | O95994 |
Chromosome Location : | 7p21.3 |
Function : | protein binding |
Products Types
◆ Recombinant Protein | ||
Agr2-502R | Recombinant Rat Agr2 Protein, His-tagged | +Inquiry |
AGR2-292H | Recombinant Human AGR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Agr2-1560M | Recombinant Mouse Agr2 Protein, Myc/DDK-tagged | +Inquiry |
AGR2-101R | Recombinant Rhesus Macaque AGR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AGR2-520H | Recombinant Human AGR2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
AGR2-8972HCL | Recombinant Human AGR2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionHigh levels of AGR2 expression have been associated with poorer prognosis in several types of cancer, indicating its potential as a prognostic biomarker.
AGR2 promotes cancer cell migration and invasion by modulating signaling pathways involved in epithelial-to-mesenchymal transition (EMT) and extracellular matrix remodeling.
AGR2 has been implicated in protein folding, quality control, and secretion of other proteins. It is also involved in cancer progression and metastasis.
AGR2 is upregulated in response to ER stress and helps restore ER homeostasis by promoting protein folding and reducing ER stress-induced apoptosis.
AGR2 acts as a chaperone protein, facilitating the correct folding of secretory proteins and assisting in their quality control before secretion.
Several small molecules and antibodies targeting AGR2 have been developed as potential therapeutic agents, but further research is needed to validate their efficacy.
Some genetic variants in the AGR2 gene have been associated with an increased risk of certain cancers, including prostate and breast cancer.
AGR2 is overexpressed in various cancers, including breast, prostate, lung, and ovarian cancers, and has been associated with tumor growth, invasion, and drug resistance.
AGR2 can activate signaling pathways such as the PI3K/AKT pathway, Wnt/β-catenin pathway, and MAPK/ERK pathway, which are involved in cell survival, proliferation, and migration.
Yes, elevated levels of AGR2 have been detected in the blood and tissue samples of cancer patients, making it a potential biomarker for cancer diagnosis.
Customer Reviews (5)
Write a reviewVery impressed.
Excellent value for its price
The customer support was also excellent, providing prompt assistance when needed.
The customer service was responsive and assisted me with technical questions.
The purity and activity of the protein were exceptional, and it worked perfectly in my experiments.
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