Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human LBP, His-tagged

Cat.No. : LBP-505H
Product Overview : Recombinant Human LBP (Accession # CAA67226) Ala26-Val481, fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Ala26
Form : Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Bio-activity : Measured by its ability to enhance LPS-stimulated IL-8 secretion by THP-1 human acute monocytic leukemia cells.The ED50 for this effect is typically 0.25 - 1.5 ng/mL.
Molecular Mass : Recombinant Human LBP, His-tagged has a calculated MW of 51.7 kDa. In SDS-PAGE migrates as 60-65 kDa, reducing conditions.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 100 µg/mL in PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : LBP lipopolysaccharide binding protein [ Homo sapiens ]
Official Symbol : LBP
Synonyms : LBP; lipopolysaccharide binding protein; lipopolysaccharide-binding protein; BPI fold containing family D; member 2; BPIFD2; LPS-binding protein; BPI fold containing family D, member 2; MGC22233;
Gene ID : 3929
mRNA Refseq : NM_004139
Protein Refseq : NP_004130
MIM : 151990
UniProt ID : P18428
Chromosome Location : 20q11.23

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What happens if LPS cannot make close contact with TLR4? 10/17/2022

If LPS's chemical spatial configuration prevents close contact with TLR4, it exhibits an antagonistic effect, inhibiting the cellular response.

What is the role of Toll-like receptor 4 (TLR4) in this process? 04/21/2022

LPS on the LBP-LPS complex, upon close physical contact with TLR4 on cells, induces TLR4 receptor dimerization or multimerization. This activates various transcription factors, leading to the expression of inflammatory mediators and cytokines.

How does the LBP-LPS complex interact with cells lacking mCD14 receptors? 03/21/2021

For cells without membrane CD14 receptors (e.g., endothelial and epithelial cells), a soluble CD14 (sCD14)-LBP-LPS ternary complex forms, activating TLR4 and inducing various biological effects.

What does LBP stand for? 09/17/2018

LBP stands for Lipopolysaccharide-Binding Protein.

What is the main function of LBP? 02/09/2018

LBP has a high affinity for the lipid A portion in the structure of Lipopolysaccharide (LPS) and forms the LPS-LBP complex.

What is the significance of the LPS-LBP complexes in liver cells? 12/02/2016

Liver cells, similar to macrophages, express mCD14 and TLR4. In the absence of CD14 receptors, LPS can still bind to TLR4, but with relatively weaker intensity.

How does the LBP-LPS complex interact with cells? 08/04/2016

The LBP-LPS complex can transfer LPS to membrane CD14 (mCD14) receptors on cells like monocytes, macrophages, and neutrophils.

Customer Reviews (3)

Write a review
Reviews
12/15/2022

    We appreciated the product's efforts to minimize its environmental footprint through sustainable manufacturing practices.

    10/24/2021

      Its adaptability to various sample types and conditions made it a valuable asset for our diverse projects.

      10/27/2018

        The product's versatility allowed us to apply it to a wide range of experimental techniques and research areas.

        Ask a Question for All LBP Products

        Required fields are marked with *

        My Review for All LBP Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends