Recombinant Human BCL2L1 protein, His-tagged
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|Product Overview :||Recombinant Human BCL2L1 (Met1-Arg212) protein was fused to His-tag at C-terminus and expressed in E.coli.|
|Description :||Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1/Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1/Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.|
|Predicted N Terminal :||Met1|
|Form :||Lyophilized from 0.22 μm filtered solution in 20 mM HEPES, 50 mM KCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 24.6 kDa. The protein migrates as 26-28 kDa under reducing (R) condition (SDS-PAGE).|
|Protein length :||Met1-Arg212|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>92% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of BCL2L1-511H :||
Human Bcl-x, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.
|Gene Name :||BCL2L1|
|Official Symbol :||BCL2L1|
|Synonyms :||BCL2L1; BCL2-like 1; bcl-2-like protein 1; Bcl X; bcl xL; bcl xS; BCL2L; BCLX; PPP1R52; protein phosphatase 1; regulatory subunit 52; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; BCL-XL/S; DKFZp781P2092|
|Gene ID :||598|
|mRNA Refseq :||NM_001191|
|Protein Refseq :||NP_001182|
|UniProt ID :||Q07817|
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