Recombinant Human MBNL1, MYC/DDK-tagged MBNL1-2736H

Recombinant Human MBNL1, MYC/DDK-tagged


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Recombinant Human MBNL1, MYC/DDK-tagged

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Cat.No. : MBNL1-2736H
Product Overview : Recombinant full-length Human MBNL1, transcript variant 5, fused with C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It has been implicated in Myotonic dystrophy and has been shown to autoregulate its transcript. Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins.
Source : HEK293 cells
Species : Human
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 34 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MBNL1 muscleblind-like splicing regulator 1 [ Homo sapiens ]
Official Symbol : MBNL1
Synonyms : EXP; MBNL; EXP35; EXP40; EXP42; muscleblind-like protein 1; triplet-expansion RNA-binding protein
Gene ID : 4154
mRNA Refseq : NM_207295
Protein Refseq : NP_997178
MIM : 606516
UniProt ID : Q9NR56
Chromosome Location : 3q25
Pathway : Adipogenesis, organism-specific biosystem
Function : RNA binding; double-stranded RNA binding; metal ion binding

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