Recombinant Human NRF1, MYC/DDK-tagged

• Cat.No.: NRF1-2152H
• Product Overview: Recombinant Human NRF1, transcript variant 2, fused with C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 53.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Usage: This product is for research and development use only. Not for use in human.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: NRF1 nuclear respiratory factor 1 [ Homo sapiens ]
• Official Symbol: NRF1
• Synonyms: ALPHA-PAL; nuclear respiratory factor 1; alpha palindromic-binding protein
• Gene ID: 4899
• mRNA Refseq: NM_001040110
• Protein Refseq: NP_001035199
• MIM: 600879
• UniProt ID: Q16656
• Chromosome Location: 7q32
• Pathway: Energy Metabolism, organism-specific biosystem; Huntington's disease, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; protein binding