Recombinant Human CDH2, Fc tagged CDH2-316H

Recombinant Human CDH2, Fc tagged

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Recombinant Human CDH2, Fc tagged

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Cat.No. : CDH2-316H
Product Overview : Recombinant Human CDH2 fussed with Fc tag was expressed in NS0 cell.
Description : This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
Source : NS0 cell
Species : Human
Tag : Fc
Predicted N Terminal : Asp160
Form : Lyophilized from a 0.2 µm filtered solution in Tris-Citrate. See Certificate of Analysis for details.
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of U-118-MG human glioblastoma/astrocytoma cells.When 5 x 10^4 cells/well are added to Recombinant Human N-Cadherin Fc Chimera coated plates (10 µg/mL, 100 µL/well), =55% will adhere after 1 hour at room temperature.
Molecular Mass : Predicted Molecular Mass:89.2 kDa (monomer);SDS-PAGE:115 - 130 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Stability : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Shipping : Reconstitute at 100 µg/mL in sterile, deionized water containing 2 mM calcium 24 hours prior to use.
Gene Name : CDH2 cadherin 2, type 1, N-cadherin (neuronal) [ Homo sapiens ]
Official Symbol : CDH2
Synonyms : CDH2; cadherin 2, type 1, N-cadherin (neuronal); NCAD; cadherin-2; CD325; CDHN; N cadherin; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal; CDw325;
Gene ID : 1000
mRNA Refseq : NM_001792
Protein Refseq : NP_001783
MIM : 114020
UniProt ID : P19022
Chromosome Location : 18q12.1
Pathway : Adherens junctions interactions, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; CDO in myogenesis, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem;
Function : RPTP-like protein binding; alpha-catenin binding; beta-catenin binding; calcium ion binding; gamma-catenin binding; protein kinase binding; protein phosphatase binding;

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