Recombinant Human CDH2, Fc tagged


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Recombinant Human CDH2, Fc tagged

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Cat.No. : CDH2-316H
Product Overview : Recombinant Human CDH2 fussed with Fc tag was expressed in NS0 cell.
Description : This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
Source : NS0 cell
Species : Human
Tag : Fc
Predicted N Terminal : Asp160
Form : Lyophilized from a 0.2 µm filtered solution in Tris-Citrate. See Certificate of Analysis for details.
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of U-118-MG human glioblastoma/astrocytoma cells.When 5 x 10^4 cells/well are added to Recombinant Human N-Cadherin Fc Chimera coated plates (10 µg/mL, 100 µL/well), =55% will adhere after 1 hour at room temperature.
Molecular Mass : Predicted Molecular Mass:89.2 kDa (monomer);SDS-PAGE:115 - 130 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Stability : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Shipping : Reconstitute at 100 µg/mL in sterile, deionized water containing 2 mM calcium 24 hours prior to use.
Gene Name : CDH2 cadherin 2, type 1, N-cadherin (neuronal) [ Homo sapiens ]
Official Symbol : CDH2
Synonyms : CDH2; cadherin 2, type 1, N-cadherin (neuronal); NCAD; cadherin-2; CD325; CDHN; N cadherin; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal; CDw325;
Gene ID : 1000
mRNA Refseq : NM_001792
Protein Refseq : NP_001783
MIM : 114020
UniProt ID : P19022
Chromosome Location : 18q12.1
Pathway : Adherens junctions interactions, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; CDO in myogenesis, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem;
Function : RPTP-like protein binding; alpha-catenin binding; beta-catenin binding; calcium ion binding; gamma-catenin binding; protein kinase binding; protein phosphatase binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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