Recombinant Human DNER Protein, Fc Chimera


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Recombinant Human DNER Protein, Fc Chimera

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Cat.No. : DNER-821H
Product Overview : Recombinant Human DNER (Accession # NP_620711), fused with , was produced in Mouse myeloma cell line, NS0-derived.
Source : Mammalian cells
Species : Human
Tag : Fc
Predicted N Terminal : Arg29
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit Pleiotrophin-induced neurite outgrowth of E16-E18 rat embryonic cortical neurons.When 4 x 10^4 neurons/well are added to 96-well plate containing serial dilutions of recombinant human DNER Fc chimera and immobilized recombinant human Pleiotrophin/PTN (1 µg/mL), neurite outgrowth is significantly inhibited in a dose dependent manner. The ED50 for this effect is typically 0.4 - 1.6 µg/mL.
Molecular Mass : Recombinant Human DNER, Fc Chimera has a calculated MW of 90.9 kDa (monomer). In SDS-PAGE migrates as 135-160 kDa, reducing conditions.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : DNER delta/notch-like EGF repeat containing [ Homo sapiens ]
Official Symbol : DNER
Synonyms : DNER; delta/notch-like EGF repeat containing; delta and Notch-like epidermal growth factor-related receptor; bet; UNQ26; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane;
Gene ID : 92737
mRNA Refseq : NM_139072
Protein Refseq : NP_620711
MIM : 607299
UniProt ID : Q8NFT8
Chromosome Location : 2q36.3
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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