Active Recombinant Human AMICA1 Protein, Fc Chimera
Cat.No. : | AMICA1-839H |
Product Overview : | Recombinant Human AMICA1 (Accession # NP_694938), fused with , was produced in Mouse myeloma cell line, NS0-derived. |
- Specification
- Gene Information
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Source : | Mammalian cells |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Leu10 |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Bio-activity : | Measured by the ability of the immobilized protein to support the adhesion of BT-20 human breast cancer cells.When 5 x 10^4 cells/well are added to rhAMICA/Fc Chimera coated plates (10 µg/mL, 100 µL/well), approximately 55% - 75% will adhere after 1 hour at 37° C. Similar results were obtained using HeLa, A549, and T84 cell-lines. Optimal dilutions should be determined by each laboratory for each application. |
Molecular Mass : | Recombinant Human AMICA1, Fc Chimera has a calculated MW of 55.5 kDa (monomer). In SDS-PAGE migrates as 65-70 kDa, reducing conditions. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Reconstitution : | Reconstitute at 0.2 mg/mL in sterile, deionized water. |
Gene Name : | AMICA1 adhesion molecule, interacts with CXADR antigen 1 [ Homo sapiens ] |
Official Symbol : | AMICA1 |
Synonyms : | AMICA1; adhesion molecule, interacts with CXADR antigen 1; junctional adhesion molecule-like; AMICA; Gm638; adhesion molecule AMICA; junctional adhesion molecule; dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; adhesion molecule interacting with CXADR antigen 1; adhesion molecule that interacts with CXADR antigen 1; JAML; CREA7-1; CREA7-4; FLJ37080; MGC118814; MGC118815; |
Gene ID : | 120425 |
mRNA Refseq : | NM_001098526 |
Protein Refseq : | NP_001091996 |
MIM : | 609770 |
UniProt ID : | Q86YT9 |
Chromosome Location : | 11q23.3 |
Products Types
◆ Recombinant Protein | ||
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Amica1-10519M | Recombinant Mouse Amica1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Amica1-973M | Recombinant Mouse Amica1 protein(Met1-Leu281), hFc-tagged | +Inquiry |
AMICA1-142R | Recombinant Rhesus Macaque AMICA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AMICA1-11H | Recombinant Human AMICA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AMICA1-001MCL | Recombinant Mouse AMICA1 cell lysate | +Inquiry |
AMICA1-2634HCL | Recombinant Human AMICA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionActivation of AMICA1 triggers downstream signaling pathways, such as Rho GTPases, PI3K/AKT, or MAPK/ERK, which modulate cytoskeletal rearrangement, cell survival, and gene expression, impacting cellular functions.
AMICA1 contributes to the formation and maintenance of tissue architecture by promoting cell adhesion, regulating cell polarity, and facilitating tissue-specific cellular organization.
AMICA1 exhibits a tissue-specific expression pattern, with higher expression observed in epithelial tissues, neural tissues, and certain organs like the liver and kidney.
Targeting AMICA1 signaling or interaction with specific antibodies or small molecules holds potential as a therapeutic strategy for diseases associated with abnormal cell adhesion or tissue integrity.
AMICA1 interacts with various cell adhesion molecules, such as cadherins, integrins, or selectins, as well as extracellular matrix components like collagen or fibronectin, facilitating cell-cell and cell-matrix interactions.
AMICA1 can undergo post-translational modifications, including phosphorylation, glycosylation, or ubiquitination, which can affect its adhesive properties, intracellular signaling, or protein stability.
During development and tissue regeneration, AMICA1 expression is dynamically regulated, showing distinct spatiotemporal patterns that coincide with tissue remodeling and organogenesis.
AMICA1 plays a crucial role in cell-cell adhesion and cell migration processes, promoting the formation of stable intercellular junctions and regulating cellular movement and tissue morphogenesis.
Dysregulation of AMICA1 expression or function has been implicated in various diseases, including cancer metastasis, epithelial barrier dysfunction, or neurodevelopmental disorders, underscoring its involvement in disease pathogenesis.
Modulation of AMICA1 expression or activity can influence cellular phenotypes, including cell proliferation, differentiation, and cell fate determination, highlighting its role in tissue homeostasis and development.
Customer Reviews (3)
Write a reviewCompatibility with complex biological matrices for translational research.
Enhanced assay sensitivity for detection of subtle protein changes.
Accurate determination of protein function and activity.
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