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Recombinant Human BMPR1B Protein, Fc Chimera

Cat.No.: BMPR1B-889H
Product Overview: Recombinant Human BMPR1B (Accession # O00238), fused with , was produced in Mouse myeloma cell line, NS0-derived.
Source: NSO Cells
Species: Human
Tag: Fc
Predicted N Terminal: Met
Form: Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity: Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351.The ED50 for this effect is typically 0.5 - 1.5 µg/mL in the presence of 30 ng/mL of rhBMP-4.
Molecular Mass: Recombinant Human BMPR1B, Fc Chimera has a calculated MW of 40 kDa (monomer). In SDS-PAGE migrates as 50-55 kDa, reducing conditions.
Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name: BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]
Official Symbol: BMPR1B
Synonyms: BMPR1B; bone morphogenetic protein receptor, type IB; bone morphogenetic protein receptor type-1B; ALK6; CDw293; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase; ALK-6;
Gene ID: 658
mRNA Refseq: NM_001203
Protein Refseq: NP_001194
MIM: 603248
UniProt ID: O00238
Chromosome Location: 4q23-q24

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