Recombinant Human STAMBP, His-tagged STAMBP-179H

Recombinant Human STAMBP, His-tagged

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Recombinant Human STAMBP, His-tagged

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Cat.No. : STAMBP-179H
Product Overview : Recombinant Human AMSHcore protein, fused with His tag, was expressed in E. coli.
Description : AMSHcore (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSHcore mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM.
Source : E. coli
Species : Human
Tag : His
Form : Liquid
Molecular Mass : 20.5 kDa
Storage : Store at -80°C, avoiding repeated freeze-thaw cycles.
Gene Name : STAMBP STAM binding protein [ Homo sapiens ]
Official Symbol : STAMBP
Synonyms : STAMBP; STAM binding protein; STAM-binding protein; AMSH; endosome-associated ubiquitin isopeptidase; associated molecule with the SH3 domain of STAM; MGC126516; MGC126518;
Gene ID : 10617
mRNA Refseq : NM_006463
Protein Refseq : NP_006454
MIM : 606247
UniProt ID : O95630
Chromosome Location : 2p24.3-p24.1
Pathway : Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Internalization of ErbB1, organism-specific biosystem;
Function : metal ion binding; metallopeptidase activity; peptidase activity; protein binding;

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