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Recombinant Human HHLA2 protein, Fc-tagged

Cat.No. : HHLA2-548H
Product Overview : Recombinant Human HHLA2 (Ile23-Asn344) protein was fused to human IgG1 Fc tag tag at C-terminus and expressed in human 293 cells (HEK293).
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  • Gene Information
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Description : B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Ile23
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 63.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Ile23-Asn344
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by reduced SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : HHLA2
Official Symbol : HHLA2
Synonyms : HHLA2; HERV-H LTR-associating 2; HERV-H LTR-associating protein 2; human endogenous retrovirus-H long terminal repeat-associating protein 2
Gene ID : 11148
mRNA Refseq : NM_007072
Protein Refseq : NP_009003
MIM : 604371
UniProt ID : Q9UM44

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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