Recombinant Human TARBP2, His-tagged

• Cat.No.: TARBP2-8654H
• Product Overview: Recombinant Human TARBP2 transcript variant 2, full length, fussed with His tag at N-terminal was expressed in E. coli.

Specification

• Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 36.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TARBP2 TAR (HIV-1) RNA binding protein 2 [ Homo sapiens ]
• Official Symbol: TARBP2
• Synonyms: LOQS; TRBP; TRBP1; TRBP2; RISC-loading complex subunit TARBP2; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2; trans-activation responsive RNA-binding protein; trans-activation-responsive RNA-binding protein
• Gene ID: 6895
• mRNA Refseq: NM_134324
• Protein Refseq: NP_599151
• MIM: 605053
• UniProt ID: Q15633
• Chromosome Location: 12q13.13
• Pathway: Gene Expression, organism-specific biosystem; MicroRNA (miRNA) biogenesis, organism-specific biosystem; Small interfering RNA (siRNA) biogenesis, organism-specific biosystem
• Function: double-stranded RNA binding; miRNA binding; contributes_to pre-miRNA binding