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Recombinant Human PRKCH protein, His-tagged

Cat.No. : PRKCH-18H
Product Overview : Recombinant Human PRKCH (Phe355~Phe614) fussed with His tag at N-terminal was expressed in E. coli.
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Description : Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
Source : E. coli
Species : Human
Tag : His
Form : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Molecular Mass : 31.2kDa
AA Sequence : MGHHHHHHSGSEF- FEFIRV LGKGSFGKVM LARVKETGDL YAVKVLKKDV ILQDDDVECT MTEKRILSLA RNHPFLTQLF CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR FDEARARFYA AEIISALMFL HDKGIIYRDL KLDNVLLDHE GHCKLADFGM CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM GVLLYEMLCG HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL TQGGEHAILR HPFF
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : SDS-PAGE; WB; ELISA; IP.
Usage : FOR IN VITRO AND RESEARCH USE ONLY, NOT FOR USE IN CLINICAL DIAGNOSTIC PROCEDURES
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigradefor one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : PRKCH protein kinase C, eta [ Homo sapiens ]
Official Symbol : PRKCH
Synonyms : PKCL; PKC-L; PRKCL; nPKC-eta; protein kinase C eta type
Gene ID : 5583
mRNA Refseq : NM_006255
Protein Refseq : NP_006246
MIM : 605437
UniProt ID : P24723
Chromosome Location : 14q23.1
Pathway : Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Effects of PIP2 hydrolysis, organism-specific biosystem; Endothelins, organism-specific biosystem
Function : ATP binding; Ral GTPase binding; calcium-independent protein kinase C activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials targeting PRKCH for therapeutic interventions? 11/19/2022

Yes, there are ongoing clinical trials exploring the potential of PRKCH as a therapeutic target in various diseases, including cancer and autoimmune disorders.

Is PRKCH protein involved in cardiovascular diseases, and how might it be targeted for therapeutic interventions? 10/27/2022

Yes, PRKCH has been implicated in cardiovascular diseases, and research is ongoing to explore its potential as a therapeutic target for conditions like hypertension and atherosclerosis.

Can PRKCH protein be a biomarker for certain diseases? 06/22/2019

Some studies suggest that altered levels of PRKCH could serve as a biomarker for certain diseases, aiding in early diagnosis and prognosis.

Are there any known genetic variations in the PRKCH gene associated with disease susceptibility? 06/09/2019

Genetic variations in the PRKCH gene have been investigated for their association with diseases, including autoimmune disorders and certain cancers.

In which clinical conditions is the expression of PRKCH protein dysregulated? 12/21/2018

Dysregulation of PRKCH has been observed in conditions such as autoimmune diseases, neurodegenerative disorders, and cardiovascular diseases.

Customer Reviews (3)

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01/30/2023

    The high-quality PRKCH protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.

    11/18/2022

      PRKCH protein demonstrates great utility in protein electron microscopy structure analysis.

      04/03/2016

        In WB experiments, PRKCH protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.

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