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Recombinant Human PTPRN protein, DDK-tagged

Cat.No.: PTPRN-256H
Product Overview: Recombinant Human PTPRN(35-575aa), transcript variant 1, fussed with DDK tag at C-terminal was expressed in HEK293 cells.
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
Source: HEK293 cells
Species: Human
Tag: DDK
Form: 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
Molecular Mass: 57.3 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: PTPRN protein tyrosine phosphatase, receptor type, N [ Homo sapiens ]
Official Symbol: PTPRN
Synonyms: IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
Gene ID: 5798
mRNA Refseq: NM_002846
Protein Refseq: NP_002837
MIM: 601773
UniProt ID: Q16849
Chromosome Location: 2q35-q36.1
Pathway: Type I diabetes mellitus, organism-specific biosystem; Type I diabetes mellitus, conserved biosystem
Function: GTPase binding; protein binding; NOT protein tyrosine phosphatase activity

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