"IAPP" Related Products


Recombinant Human IAPP protein, MYC/DDK-tagged

Cat.No.: IAPP-28H
Product Overview: Recombinant Human IAPP fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.
Description: Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
Source: HEK293 cells
Species: Human
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 3.9 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: IAPP islet amyloid polypeptide [ Homo sapiens ]
Official Symbol: IAPP
Synonyms: DAP; IAP; islet amyloid polypeptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); amylin; diabetes-associated peptide; insulinoma amyloid peptide
Gene ID: 3375
mRNA Refseq: NM_000415
Protein Refseq: NP_000406
MIM: 147940
UniProt ID: P10997
Chromosome Location: 12p12.1
Pathway: Amyloids, organism-specific biosystem; Calcitonin-like ligand receptors, organism-specific biosystem; Disease, organism-specific biosystem
Function: hormone activity; identical protein binding; receptor binding

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