"CCND3" Related Products

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Recombinant Human CCND3 protein, His/T7-tagged

Cat.No.: CCND3-840H
Product Overview: Recombinant Human CCND3 (Met1~Leu292) fussed with His-tag and T7-ta at N-terminal was expressed in E. coli.
Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
Source: E. coli
Species: Human
Tag: His/T7
Form: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Molecular Mass: 36.3kDa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR EIKPHMRKML AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ LLGAVCMLLA SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW DLAAVIAHDF LAFILHRLSL PRDRQALVKK HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL RACQEQIEAA LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL
Endotoxin: <1.0EU per 1µg (determined by the LAL method)
Purity: > 95%
Applications: SDS-PAGE; WB; ELISA; IP.
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name: CCND3 cyclin D3 [ Homo sapiens ]
Official Symbol: CCND3
Synonyms: G1/S-specific cyclin-D3; D3-type cyclin
Gene ID: 896
mRNA Refseq: NM_001760
Protein Refseq: NP_001751
MIM: 123834
UniProt ID: P30281
Chromosome Location: 6p21
Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell cycle - G1/S transition, organism-specific biosystem
Function: cyclin-dependent protein serine/threonine kinase activity; protein binding; protein kinase binding

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