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Recombinant Human CYP46A1 protein, MYC/DDK-tagged

Cat.No. : CYP46A1-258H
Product Overview : Recombinant Human CYP46A1 fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 56.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 [ Homo sapiens ]
Official Symbol : CYP46A1
Synonyms : CP46; CYP46; cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Gene ID : 10858
mRNA Refseq : NM_006668
Protein Refseq : NP_006659
MIM : 604087
UniProt ID : Q9Y6A2
Chromosome Location : 14q32.1
Pathway : Bile acid and bile salt metabolism, organism-specific biosystem; Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem
Function : cholesterol 24-hydroxylase activity; heme binding; iron ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CYP46A1 protein be used as a biomarker for neurodegenerative diseases? 04/18/2023

Research suggests that altered CYP46A1 activity and expression may serve as a biomarker for neurodegenerative diseases and could aid in early detection and monitoring of disease progression.

How does CYP46A1 protein influence the development and progression of Huntington's disease? 02/03/2023

Dysregulation of CYP46A1-mediated cholesterol metabolism has been implicated in the pathogenesis of Huntington's disease, making it a potential therapeutic target.

Can CYP46A1 protein be targeted for therapeutic interventions in neurodegenerative diseases? 05/04/2021

Research is investigating the potential of targeting CYP46A1 for therapeutic interventions, such as the development of small molecule modulators to regulate its activity.

How does CYP46A1 protein impact the efficacy of cholesterol-lowering drugs? 11/19/2020

CYP46A1 activity influences the clearance of cholesterol from the brain, which may interact with the effects of cholesterol-lowering drugs, potentially affecting their efficacy.

Are there any genetic variations in the CYP46A1 gene associated with clinical conditions? 09/17/2018

Some genetic variations in the CYP46A1 gene have been linked to altered CYP46A1 activity and an increased risk of neurodegenerative diseases.

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11/24/2022

    They can also address any questions or concerns regarding the CYP46A1 protein, thereby facilitating smooth and efficient research execution.

    02/21/2017

      manufacturers may offer customization options, allowing researchers to tailor the CYP46A1 protein to their specific needs.

      05/08/2016

        This may include options like different formulations, protein modifications, or tagging techniques. Customization can enhance the versatility of the protein and optimize its utility in the intended research.

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