Recombinant Human CYP46A1 protein, MYC/DDK-tagged CYP46A1-258H

Recombinant Human CYP46A1 protein, MYC/DDK-tagged


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Recombinant Human CYP46A1 protein, MYC/DDK-tagged

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Cat.No. : CYP46A1-258H
Product Overview : Recombinant Human CYP46A1 fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Source : HEK293 cells
Species : Human
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 56.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 [ Homo sapiens ]
Official Symbol : CYP46A1
Synonyms : CP46; CYP46; cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Gene ID : 10858
mRNA Refseq : NM_006668
Protein Refseq : NP_006659
MIM : 604087
UniProt ID : Q9Y6A2
Chromosome Location : 14q32.1
Pathway : Bile acid and bile salt metabolism, organism-specific biosystem; Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem
Function : cholesterol 24-hydroxylase activity; heme binding; iron ion binding

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