Recombinant Human RNASEH1 protein, MYC/DDK-tagged RNASEH1-4321H

Recombinant Human RNASEH1 protein, MYC/DDK-tagged

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Recombinant Human RNASEH1 protein, MYC/DDK-tagged

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Cat.No. : RNASEH1-4321H
Product Overview : Recombinant Human RNASEH1 fussed with MYC/DDK tag at C-terminal was expressed in HEK293.
Description : This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes; two of them are on different locations of chromosome 17 and one of them is on chromosome 1q32.2.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 31.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : RNASEH1 ribonuclease H1 [ Homo sapiens ]
Official Symbol : RNASEH1
Synonyms : RNASEH1; ribonuclease H1; RNase H1; ribonuclease H type II; RNH1; H1RNA;
Gene ID : 246243
mRNA Refseq : NM_002936
Protein Refseq : NP_002927
MIM : 604123
UniProt ID : O60930
Chromosome Location : 2p25
Pathway : DNA replication, organism-specific biosystem; DNA replication, conserved biosystem;
Function : RNA binding; endonuclease activity; hydrolase activity; magnesium ion binding; nucleic acid binding; protein homodimerization activity; ribonuclease H activity; ribonuclease activity;

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