Recombinant Human NGFR, Fc-tagged, Biotinylated


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Recombinant Human NGFR, Fc-tagged, Biotinylated

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Cat.No. : NGFR-653H
Product Overview : The recombinant human NGFR-Fc fusion is expressed as a 450 amino acid protein consisting of Lys29 -Asn250 region of NGFR (UniProt accession #P08138) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its ligand NGF and inhibits NGF dependent proliferation of human TF-1 erythroleukemic cells.
Molecular Mass : Calculated molecular mass (kDa): 49.1; Estimated by SDS-PAGE under reducing condition (kDa): 70-80
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : NGFR nerve growth factor receptor [ Homo sapiens ]
Official Symbol : NGFR
Synonyms : NGFR; nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16; CD271; low affinity nerve growth factor receptor; p75NTR; TNFR superfamily; member 16; TNFRSF16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; p75(NTR); Gp80-LNGFR;
Gene ID : 4804
mRNA Refseq : NM_002507
Protein Refseq : NP_002498
MIM : 162010
UniProt ID : P08138
Chromosome Location : 17q21-q22
Pathway : Axonal growth inhibition (RHOA activation), organism-specific biosystem; Axonal growth stimulation, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Ceramide signalling, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; NADE modulates death signalling, organism-specific biosystem;
Function : death receptor activity; nerve growth factor binding; protein binding; receptor activity; signal transducer activity; transmembrane signaling receptor activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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