Recombinant Human TNFRSF12A, Fc-tagged, Biotinylated TNFRSF12A-709H

Recombinant Human TNFRSF12A, Fc-tagged, Biotinylated

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Recombinant Human TNFRSF12A, Fc-tagged, Biotinylated

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Cat.No. : TNFRSF12A-709H
Product Overview : The recombinant human TWEAKR-Fc fusion is expressed as a 281 amino acid protein consisting of Glu28- Pro80 region of TWEAKR (UniProt accession #Q9NP84) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its ligand TWEAK/TNFSF12 and inhibits TWEAK-mediated signaling activities including TWEAK--induced apoptosis in HT-29 human colon cancer cells and proliferation of human umbilical vein endothelial cells (HUVECs).
Molecular Mass : Calculated molecular mass (kDa): 31.1; Estimated by SDS-PAGE under reducing condition (kDa): ~40
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition.
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : TNFRSF12A tumor necrosis factor receptor superfamily, member 12A [ Homo sapiens ]
Official Symbol : TNFRSF12A
Synonyms : TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; tumor necrosis factor receptor superfamily member 12A; CD266; FN14; TweakR; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14; TWEAKR;
Gene ID : 51330
mRNA Refseq : NM_016639
Protein Refseq : NP_057723
MIM : 605914
UniProt ID : Q9NP84
Chromosome Location : 16p13.3
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : protein binding; receptor activity;

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