Recombinant Human SNCA protein

Cat.No.: SNCA-237H
Product Overview: Recombinant Human SNCA(amino acids 96-140) was expressed in E. coli.
Description: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Source: E. coli
Species: Human
Predicted N Terminal: Met
Form: Supplied as a liquid In 20mM Tris-HCl buffer, pH 7.5, containing 0.1 M NaCl.
Molecular Mass: 5.2 kDa (46 aa), confirmed by MALDI-TOF.
Protein length: amino acids 96-140
AA Sequence: MKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Purity: > 95% by SDS - PAGE
Applications: SDS-PAGE
Notes: Small volumes of alpha Synuclein 96140 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage: Store at 4 centigrade for short term storage (1/2 weeks). Aliquot and store at -20 centigrade or - 70 centigrade for long term storage. Avoid repeated freeze/thaw cycles.
Concentration: 1 mg/ml (lot specific)
Gene Name: SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ]
Official Symbol: SNCA
Synonyms: SNCA; synuclein, alpha (non A4 component of amyloid precursor); PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4; alpha-synuclein; alpha synuclein; NACP; PD1; synuclein alpha-140; non A-beta component of AD amyloid; PARK1; PARK4; MGC110988;
Gene ID: 6622
mRNA Refseq: NM_000345
Protein Refseq: NP_000336
MIM: 163890
UniProt ID: P37840
Chromosome Location: 4q21.3-q22
Pathway: Alpha-synuclein signaling, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Parkinsons disease, organism-specific biosystem;
Function: Hsp70 protein binding; alpha-tubulin binding; arachidonic acid binding; calcium ion binding; copper ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; dynein binding; NOT fatty acid binding; ferrous iron binding; histone binding; identical protein binding; kinesin binding; magnesium ion binding; oxidoreductase activity; NOT phospholipase D inhibitor activity; phosphoprotein binding; protein binding; tau protein binding; zinc ion binding;

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