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Recombinant Human RNASEL protein, MYC/DDK-tagged

Cat.No. : RNASEL-39H
Product Overview : Recombinant Human RNASEL(His19-Glu563) fussed with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 83.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : RNASEL ribonuclease L (2,5-oligoisoadenylate synthetase-dependent) [ Homo sapiens ]
Official Symbol : RNASEL
Synonyms : RNASEL; ribonuclease L (2,5-oligoisoadenylate synthetase-dependent); PRCA1, prostate cancer 1 , RNS4; 2-5A-dependent ribonuclease; RNase L; ribonuclease 4; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; 2,5-oligoisoadenylate synthetase-dependent; RNS4; PRCA1; MGC104972; MGC133329; DKFZp781D08126;
Gene ID : 6041
mRNA Refseq : NM_021133
Protein Refseq : NP_066956
MIM : 180435
UniProt ID : Q05823
Chromosome Location : 1q25
Pathway : Cytokine Signaling in Immune system, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Immune System, organism-specific biosystem; Influenza A, organism-specific biosystem;
Function : ATP binding; RNA binding; endoribonuclease activity; endoribonuclease activity, producing 5-phosphomonoesters; hydrolase activity; metal ion binding; nucleotide binding; protein kinase activity; transferase activity, transferring phosphorus-containing groups;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific dietary factors that can modulate RNASEL activity? 12/15/2022

Some studies have suggested that dietary factors, such as vitamin E and selenium, may influence RNASEL activity.

How is RNASEL protein regulated in the human body? 07/21/2022

RNASEL expression and activity are regulated by various factors, including cytokines and viral infections.

What are the potential side effects of modulating RNASEL activity for therapeutic purposes? 02/08/2019

Potential side effects may include alterations in immune response and potential impact on RNA degradation processes.

Can variations in RNASEL gene influence the response to antiviral therapies? 07/28/2017

Yes, variations in the RNASEL gene have been linked to differences in the response to antiviral therapies.

Is there a link between RNASEL protein and autoimmune diseases? 01/07/2017

Some studies have suggested a potential link between RNASEL protein and autoimmune diseases, but more research is needed to fully understand this relationship.

Customer Reviews (3)

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Reviews
09/12/2022

    I am certain that the RNASEL protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.

    02/26/2021

      The excellent technical support provided by the manufacturer can solve my problem.

      08/14/2017

        Whether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the RNASEL protein consistently delivers exceptional performance and precise outcomes.

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