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Recombinant Human NNMT protein, His-tagged

Cat.No.: NNMT-148H
Product Overview: Recombinant Human NNMT(Met1-Leu264) fused with His tag at C-terminal was expressed in E. coli.
Description: NNMT (Nicotinamide N­Methyltransferase) is a cytosolic enzyme that catalyzes the N­methylation of nicotinamide and other pyridines using S­adenosyl­L­methionine (AdoMet) as the methyl group donor. The enzyme is highly expressed in liver but is also detected in other organs. NNMT plays a significant role in nicotinamide metabolism and in the detoxification of xenobiotics. The association with thyroid cancer and renal carcinoma makes NNMT useful as a tumor biomarker.
Source: E. coli
Species: Human
Tag: His
Predicted N Terminal: Met1
Form: Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.
Bio-activity: Measured by its ability to methylate nicotinamide. The specific activity is >65 pmol/min/µg.
Molecular Mass: Predicted Molecular Mass: 30 kDa;SDS-PAGE: 25-29 kDa, reducing conditions.
Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.
Stability: Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 centigrade as supplied.3 months, -70 centigrade under sterile conditions after opening.
Gene Name: NNMT nicotinamide N-methyltransferase [ Homo sapiens ]
Official Symbol: NNMT
Synonyms: NNMT; nicotinamide N-methyltransferase;
Gene ID: 4837
mRNA Refseq: NM_006169
Protein Refseq: NP_006160
MIM: 600008
UniProt ID: P40261
Chromosome Location: 11q23.1
Pathway: Biological oxidations, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Methylation, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem; Nicotinate and nicotinamide metabolism, conserved biosystem; Phase II conjugation, organism-specific biosystem;
Function: methyltransferase activity; nicotinamide N-methyltransferase activity; transferase activity;

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