Recombinant Human POLB protein


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Recombinant Human POLB protein

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Cat.No. : POLB-621H
Product Overview : Recombinant Human POLB protein was a repair enzyme used to fill gaps and nicks in double-stranded DNA.
Species : Human
Form : 20 mM Tris-HCl (pH 8.0), 0.1 mM EDTA. 200 mM NaCl, 1 mM dithiothreitol, 50% (v/v) glycerol
Unit Definition : One unit is the amount of enzyme required to incorporate 1 pmole of total nucleotide into acid-insoluble form in 60 minutes at 37 centigrade under the stated assay conditions.
Applications : 1. Repair polymerase able to synthesize DNA beyond the end of a gap or nick with simultaneous displacement of the non-replicated strand.2. Fills gaps and nicks.
Notes : All preparations are assayed for contaminating endonuclease and exonuclease activities.
Storage : Store at -80 centigrade Long Term;Store at -20 centigrade.
Gene Name : POLB polymerase (DNA directed), beta [ Homo sapiens ]
Official Symbol : POLB
Synonyms : POLB; polymerase (DNA directed), beta; DNA polymerase beta; DNA pol beta; DNA polymerase beta subunit; MGC125976;
Gene ID : 5423
mRNA Refseq : NM_002690
Protein Refseq : NP_002681
MIM : 174760
UniProt ID : P06746
Chromosome Location : 8p12-p11
Pathway : BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; DNA Repair, organism-specific biosystem;
Function : DNA-directed DNA polymerase activity; damaged DNA binding; enzyme binding; lyase activity; metal ion binding; microtubule binding; nucleotidyltransferase activity; protein binding; transferase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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