Recombinant Human POLB protein POLB-621H

Recombinant Human POLB protein

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Recombinant Human POLB protein

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Cat.No. : POLB-621H
Product Overview : Recombinant Human POLB protein was a repair enzyme used to fill gaps and nicks in double-stranded DNA.
Species : Human
Form : 20 mM Tris-HCl (pH 8.0), 0.1 mM EDTA. 200 mM NaCl, 1 mM dithiothreitol, 50% (v/v) glycerol
Unit Definition : One unit is the amount of enzyme required to incorporate 1 pmole of total nucleotide into acid-insoluble form in 60 minutes at 37 centigrade under the stated assay conditions.
Applications : 1. Repair polymerase able to synthesize DNA beyond the end of a gap or nick with simultaneous displacement of the non-replicated strand.2. Fills gaps and nicks.
Notes : All preparations are assayed for contaminating endonuclease and exonuclease activities.
Storage : Store at -80 centigrade Long Term;Store at -20 centigrade.
Gene Name : POLB polymerase (DNA directed), beta [ Homo sapiens ]
Official Symbol : POLB
Synonyms : POLB; polymerase (DNA directed), beta; DNA polymerase beta; DNA pol beta; DNA polymerase beta subunit; MGC125976;
Gene ID : 5423
mRNA Refseq : NM_002690
Protein Refseq : NP_002681
MIM : 174760
UniProt ID : P06746
Chromosome Location : 8p12-p11
Pathway : BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; DNA Repair, organism-specific biosystem;
Function : DNA-directed DNA polymerase activity; damaged DNA binding; enzyme binding; lyase activity; metal ion binding; microtubule binding; nucleotidyltransferase activity; protein binding; transferase activity;

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