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Recombinant Human Nicotinamide Phosphoribosyltransferase

Cat. No.: NAMPT-134H, His-tagged
Product Overview: Recombinant HumanVisfatin produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 511 amino acids and having a molecular mass of 57 kDa. The recombinant human Visfatin is fused to His tag at N-Terminus.
Description: Visfatin, also known as pre-B cell colony-enhancing factor (PBEF), is a cytokine that is highly expressed in visceral fat and was originally isolated as a secreted factor that synergizes with IL-7 and stem cell factors to promote the growth of B cell precursors. Visfatin homologs have been identified in carp, invertebrate mollusks, and bacteria, as well as in vertebrates, including humans and the mouse. It has been postulated to play a role in innate immunity. Visfatin exerts insulin-mimetic effects that are dose-dependent and quantitatively similar to those of insulin in stimulating muscle and adipocyte glucose transport, and in inhibiting hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose in a dose-dependent fashion.
Source: Escherichia Coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MNPAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKLR KVKYEETVFY GLQYILNKYL KGKVVTKEKI QEAKDVYKEH FQDDVFNEKG WNYILEKYDG HLPIEIKAVP EGFVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS GNLDGLEYKL HDFGYRGVSS QETAGIGASA HLVNFKGTDT VAGLALIKKY YGTKDPVPGY SVPAAEHSTI TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV SRSTQAPLII RPDSGNPLDT VLKVLEILGK KFPVTENSKG YKLLPPYLRV IQGDGVDINT LQEIVEGMKQ KMWSIENIAF GSGGGLLQKL TRDLLNCSFK CSYVVTNGLG INVFKDPVAD PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL EEYGQDLLHT VFKNGKVTKS YSFDEIRKNA QLNIELEAAH H.
Physical Appearance: Sterile Filtered solution at a concentration of 1 mg/ml.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: Visfatin His tag protein contains 20 mM Tris pH-8, 0.1 mM DTT & 10% glycerol.
Solubility: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name: NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens ]
Synonyms: NAMPT; nicotinamide phosphoribosyltransferase; NAmPRTase; DKFZp666B131; EC 2.4.2.12; EC=2.4.2.12; PBEF; PBEF1; pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; pre-B-cell colony enhancing factor 1 TIN; VF;visfatiN; Visfatin 3; VISFANAmPRTase; 1110035O14Rik; Short name=Nampt; Short name=NAmPRTase; Short name=Pre-B cell-enhancing factor
Gene ID: 10135
mRNA Refseq: NM_005746
Protein Refseq: NP_005737
MIM: 608764
UniProt ID: P43490
Chromosome Location: 7q22.3
Pathway: Nicotinate and nicotinamide metabolism; Metabolism of vitamins and cofactors REACT_11193
Function: cytokine activity; nicotinamide phosphoribosyltransferase activity; nicotinamide phosphoribosyltransferase activity; transferase activity, transferring glycosyl groups

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