"TPMT" Related Products

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Recombinant Human Thiopurine S-methyltransferase

Cat. No.: TPMT-76H
Product Overview: Recombinant human TPMT was expressed in E.coli and purified by using conventional chromatography techniques(245 aa, 28 kDa).
Description: TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
Source: Escherichia Coli.
Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 mM PMSF, 2 mM EDTA.
Molecular Weight: 28 kDa (245 aa).
Purity: > 95% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Amino acid Sequence: MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: TPMT thiopurine S-methyltransferase [ Homo sapiens ]
Synonyms: TPMT; Thiopurine S-methyltransferase; EC 2.1.1.67; Thiopurine methyltransferase; OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase.
Gene ID: 7172
mRNA Refseq: NM_000367
Protein Refseq: NP_000358
MIM: 187680
UniProt ID: P51580
Chromosome Location: 6p22.3
Function: methyltransferase activity; thiopurine S-methyltransferase activity; transferase activity.

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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