Recombinant Human Thiopurine S-methyltransferase
Cat.No. : | TPMT-76H |
Product Overview : | Recombinant human TPMT was expressed in E.coli and purified by using conventional chromatography techniques(245 aa, 28 kDa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | TPMT-76H |
Description : | TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity. |
Source : | Escherichia Coli. |
Formulation : | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 mM PMSF, 2 mM EDTA. |
Molecular Weight : | 28 kDa (245 aa). |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Amino acid Sequence : | MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | TPMT thiopurine S-methyltransferase [ Homo sapiens ] |
Synonyms : | TPMT; Thiopurine S-methyltransferase; EC 2.1.1.67; Thiopurine methyltransferase; OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase. |
Gene ID : | 7172 |
mRNA Refseq : | NM_000367 |
Protein Refseq : | NP_000358 |
MIM : | 187680 |
UniProt ID : | P51580 |
Chromosome Location : | 6p22.3 |
Function : | methyltransferase activity; thiopurine S-methyltransferase activity; transferase activity. |
Products Types
◆ Recombinant Protein | ||
Tpmt-6602M | Recombinant Mouse Tpmt Protein, Myc/DDK-tagged | +Inquiry |
TPMT-9540M | Recombinant Mouse TPMT Protein, His (Fc)-Avi-tagged | +Inquiry |
TPMT-17260M | Recombinant Mouse TPMT Protein | +Inquiry |
TPMT-3612H | Recombinant Human TPMT protein, GST-tagged | +Inquiry |
TPMT-6503H | Recombinant Human TPMT Protein (Leu26-His227), His tagged | +Inquiry |
◆ Lysates | ||
TPMT-841HCL | Recombinant Human TPMT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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