"PTI" Related Products

Recombinant Bovine Pancreatic Trypsin Inhibitor

Cat. No. : PTI-50B
Product Overview : Recombinant Bovine Aprotinin produced inE.Coliis approximately 6,512 Dalton highly purified and designed specifically for cell culture applications, protein purification, diagnostic testing and pharmaceuticals. It is produced without the use of animal- or human-derived materials and is therefore free from risk of contaminating human or animal-derived viruses or prions.
Description : Aprotinin, also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer) is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use is to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered lyophilized powder.
Purity : Greater than 90.0%, determind by Gel Electrophoresis.
Formulation : The protein was lyophilized without any additives.
Solubility : It is recommended to reconstitute the Aprotinin in sterile 18MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity : 4.6 TIU/mg.
Unit Defenition : One Trypsin Inhibitory Unit (TIU) is equal to the amount of inhibitor with the ability to inhibit two trypsin units by 50% where one trypsin unit will hydrolyze 1.0 mole of N-alpha-benzoyl-DL-Arginine-p-Nitroanilide (BAPNA) per minute at pH 7.8 at 25°C.
Storage : Aprotinin although stable at room temperature for 3 weeks, should be stored at 4°C.
Gene Name : PTI pancreatic trypsin inhibitor [ Bos taurus ]
Synonyms : pancreatic trypsin inhibitor; PTI; BPI; BPTI; MGC148815; aprotinin; basic protease inhibitor
Gene ID : 404172
mRNA Refseq : NM_001001554
Protein Refseq : NP_001001554
UniProt ID : P00974

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