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Recombinant Human Regenerating Islet-derived 1 Beta, His-tagged

Cat.No. : REG1B-193H
Product Overview : Recombinant Human REG 1 beta (His-tagged) produced inE.colicontains 144 amino acids and has a molecular mass of 17.8 kDa.
  • Specification
  • Gene Information
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Cat. No. : REG1B-193H
Description : Reg protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. human REG cDNA which encoded a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein. Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta.
Source : E.Coli.
Sequences Of Amino Acids : MKHHHHHHAS HMQESQTELP NPRISCPEGT NAYRSYCYYF NEDPETWVDA DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI GLHDPKKNRR WHWSSGSLVS YKSWDTGSPS SANAGYCASL TSCSGFKKWK DESCEKKFSF VCKFKN.
Specificity : The amino acid sequence of the recombinant Human REG 1 beta is 100% homologous to the amino acid sequence of the Human REG 1 beta without signal sequence.
Purification Method : Two-step procedure using affinity Ni-NTA chromatography and size exclusion chromatography.
Purity : Purity of recombinant Human REG 1 beta is >95% (SDS-PAGE analyzed).
Formulation : Sterile filtered and lyophilized from 0.5 mg/ml in 20 mM Tris , pH 8.0.
Reconstitution : Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.
Stability/Shelf Life : The lyophilized protein remains stable until the expiry date when stored at -20°C.
Applications : Western blotting, ELISA.
Storage : Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Gene Name : REG1B regenerating islet-derived 1 beta [ Homo sapiens ]
Synonyms : REG1B; PSPS2; REGH; REGI-BETA; REGL; Regenerating protein I beta; lithostathine 1 beta; regenerating islet-derived 1 beta; secretory pancreatic stone protein; regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein); Regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein); secretory pancreatic stone protein 2
Gene ID : 5968
mRNA Refseq : NM_006507
Protein Refseq : NP_006498
MIM : 167771
UniProt ID : P48304
Chromosome Location : 2p12
Function : binding; sugar binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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