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Recombinant Human Troponin C Type 1 (Slow)

Cat. No.: TNNC1-138H
Product Overview: Recombinant Human troponin C type 1 (slow) produced inE. Coliis a single, non-glycosylated, polypeptide chain. The TNC has a molecular mass of 18,020 Dalton. The TNC is purified by proprietary chromatographic techniques.
Description: Troponin Complex is a heteromeric protein playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, Troponin I, Troponin T and Troponin C. Each subunit is responsible for part of Troponin Complex function. E.g. Troponin I inhibits ATP-ase activity of acto-myosin. Troponin T and Troponin I are presented in cardiac muscles in different forms than in skeletal muscles. Purified subunits of rcTnI, rcTnC and rcTnT recomplexed in vitro under appropriate conditions.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered colourless liquid formualtion.
Formulation: Each mg/ml of protein (0.5mg/ml) contains 50% glycerol.
Purity: Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained.
Dimers And Aggregates: Less than 1% as determined by silver stained SDS-PAGE gel analysis.
Endotoxin: Less than 0.1 ng/µg (IEU/µg) ofrHuTNC.
Applications: Immunoassays and western blot.
Stability: RHuTNC although stable at 10℃ for 7 days, should be stored desiccated below -18℃. Please prevent freeze-thaw cycles.
Gene Name: TNNC1 troponin C type 1 (slow) [ Homo sapiens ]
Synonyms: TNNC1; troponin C type 1 (slow); TNC; TNNC; CMD1Z; troponin C, slow; Troponin C, slow skeletal and cardiac muscles; TN-C; cardiac troponin C; troponin C1, slow; slow twitch skeletal/cardiac muscle troponin C
Gene ID: 7134
mRNA Refseq: NM_003280
Protein Refseq: NP_003271
MIM: 191040
UniProt ID: P63316
Chromosome Location: 3p21.3-p14.3
Pathway: Calcium signaling pathway; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM); Muscle contraction
Function: actin filament binding; calcium ion binding; calcium- dependent protein binding; protein homodimerization activity; troponin I binding; troponin T binding

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