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Recombinant Human XRCC5 protein, His-tagged

Cat.No. : XRCC5-149H
Product Overview : KuP70/P80 Human Recombinant produced in SF9 insect cells is a glycosylated, polypeptide chain having a molecular mass of 70,638 Dalton for the p70 subunit and 83,528 Dalton for the p80 subunit. Ku (P70/P80) is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
  • Specification
  • Gene Information
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Source : Insect cells
Species : Human
Tag : His
Form : KuP70/P80is supplied in 16mM HEPES buffer pH-8, 160mM NaCl, and 20% glycerol.
Purity : Greater than 95% as determined by SDS-PAGE.
Applications : Western-Blot with monoclonal anti-hexa-His-tag antibody & anti-Ku autoantibody-positive patient sera.
Storage : Store at 4 centigrade if entire vial will be used within 2-4 weeks.Store, frozen at -20 centigrade for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name : XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [ Homo sapiens ]
Official Symbol : XRCC5
Synonyms : XRCC5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X ray repair complementing defective repair in Chinese hamster cells 5 (double strand break rejoining; Ku autoantigen, 80kD); X-ray repair cross-complementing protein 5; KARP 1; Ku autoantigen; 80kDa; KU80; Ku86; KUB2; TLAA; CTC85; CTCBF; nuclear factor IV; Ku autoantigen, 80kDa; DNA repair protein XRCC5; thyroid-lupus autoantigen; 86 kDa subunit of Ku antigen; lupus Ku autoantigen protein p86; Ku86 autoantigen related protein 1; CTC box-binding factor 85 kDa subunit; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; NFIV; KARP1; KARP-1; FLJ39089;
Gene ID : 7520
mRNA Refseq : NM_021141
Protein Refseq : NP_066964
MIM : 194364
UniProt ID : P13010
Chromosome Location : 2q35
Pathway : 2-LTR circle formation, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; DNA Repair, organism-specific biosystem; DNA-PK complex, organism-specific biosystem; Disease, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem;
Function : contributes_to 5-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding; contributes_to double-stranded telomeric DNA binding; helicase activity; hydrolase activity, acting on acid anhydrides; nucleotide binding; protein C-terminus binding; protein binding; telomeric DNA binding; transcription regulatory region DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does XRCC5 function in DNA repair? 10/02/2022

XRCC5 forms a heterodimer with XRCC6 (Ku70) and plays a crucial role in non-homologous end joining (NHEJ) repair of DNA double-strand breaks.

What are the clinical implications of XRCC5 mutations? 07/27/2022

Mutations in XRCC5 have been associated with an increased risk of cancer and may affect the response to certain cancer treatments.

Are there diagnostic tests to detect XRCC5 mutations? 03/27/2019

Yes, genetic testing can identify XRCC5 mutations, which can be important for assessing cancer risk.

Can XRCC5 mutations lead to cancer susceptibility? 03/31/2018

Yes, mutations in XRCC5 have been linked to an increased susceptibility to certain types of cancer, such as breast and ovarian cancer.

How can XRCC5 be targeted in cancer therapy? 01/24/2018

XRCC5 inhibitors are being investigated as potential cancer therapeutics to sensitize cancer cells to radiation and chemotherapy.

Customer Reviews (3)

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Reviews
01/25/2023

    The combination of high-quality XRCC5 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

    09/09/2019

      The manufacturer's extensive experience and expertise in the field of XRCC5 protein research make them a trusted partner.

      08/03/2019

        The manufacturer's commitment to providing excellent technical support is highly valuable.

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