Recombinant Human Growth Hormone 1

• Cat.No.: GH1-80H
• Product Overview: Recombinant Human Growth Hormone 1 encoding the human growth hormone protein sequence (containing the signal peptide sequence and the mature growth hormone sequence) was expressed in modifiedhuman 293 cells.

Specification

• Cat. No.: GH1-80H
• Description: Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones. Its activity is required for normal human growth and development. It regulates an extensive variety of physiological functions relating to human growth and metabolism, primarily by inducing the expression of insulin-like growth factor 1 (IGF-1). hGH is synthesized and secreted into the circulation by acidophilic or somatotropic cells of the anterior pituitary gland in response to hGH releasing hormone (HGHR) from the hypothalamus.
• Source: Human 293 cells.
• Amino Acid Sequence: FPTIPLSRLFDNAMLRAHRLHQLAF DTYQEFEEAYIPKEQKYSFLQNPQT SLCFSESIPTPSNREETQQKSNLEL LRISLLLIQSWLEPVQFLRSVFANS LVYGASDSNVYDLLKDLEEGIQTLM GRLEDGSPRTGQIFKQTYSKFDTNS HNDDALLKNYGLLYCFRKDMDKVET FLRIVQCRSVEGSCGF.
• Molecular Mass: Growth Hormone migrates as a band with an apparent MW of 20 kDa in SDS-PAGE. This compares with the predicted molecular mass of 22.1 kDa.
• pI: Unmodified Growth Hormone has a predicted pI of 5.27.
• Purity: >95%, as determined by SDS-PAGE and visualized by silver stain.
• Formulation: When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
• Reconstitution: It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
• Storage: Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

Gene Information

• Gene Name: GH1 growth hormone 1 [ Homo sapiens ]
• Synonyms: GH1; growth hormone 1; GH; GHN; GH-N; hGH-N; IGHD1B; pituitary growth hormone
• Gene ID: 2688
• mRNA Refseq: NM_000515
• Protein Refseq: NP_000506
• UniProt ID: P01241
• Chromosome Location: 17q22-q24
• MIM: 139250
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Neuroactive ligand-receptor interaction
• Function: growth factor activity; growth hormone activity; growth hormone receptor binding; olactin receptor binding; protein binding