Recombinant Human Carbonyl Reductase 3, His-tagged

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Recombinant Human Carbonyl Reductase 3, His-tagged

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Cat. No. : CBR3-184H
Product Overview : Recombinant human CBR3, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW =33 kDa (297aa).
Description : Carbonyl reductase 3(CBR3)is one of several monomeric NADPH-dependent oxidoreductases. This protein catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. It also contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene – CBR1. Some studies suggest that it mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.
Source : E.coli.
Amino Acid Sequence : MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW
Form : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 2hrb. :

Gene Name : CBR3 carbonyl reductase 3 [ Homo sapiens ]
Synonyms : CBR3; carbonyl reductase 3; hCBR3; SDR21C2; carbonyl reductase (NADPH) 3; NADPH-dependent carbonyl reductase 3; short chain dehydrogenase/reductase family 21C, member 2; EC 1.1.1.184; short chain dehydrogenase/reductase family 21C, member 2; SDR21C2; carbonyl reductase (NADPH) 3, EC 1.1.1.184
Gene ID : 874
mRNA Refseq : NM_001236
Protein Refseq : NP_001227
MIM : 603608
UniProt ID : O75828
Chromosome Location : 21q22.2
Pathway : Arachidonic acid metabolism; Metabolic pathways
Function : NADPH binding; binding; carbonyl reductase (NADPH) activity; oxidoreductase activity

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