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Recombinant Human Phosphoserine Phosphatase

Cat. No.: PSPH-198H
Product Overview: Recombinant human Phosphoserine Phosphatase was overexpressed inE. coliand purified by conventional chromatography. MW = 25 kDa (225 aa).
Description: Human Phosphoserine phosphatase (hPSP) is an important enzyme in the phosphorylated pathway of serine biosynthesis, which contributes a major portion of the endogenous L-serine. Similar to known L-3-phosphoserine phosphatases, it catalyzed the Mg2+-dependent hydrolysis of L-phosphoserine and an exchange reaction between L-serine and L-phosphoserine. Recently, its complex structures reveal that the open-closed environmental change of the active site, generated by local rearrangement of the -helical bundle domain, is important to substrate recognition and hydrolysis.
Source: Escherichia Coli.
Form: Liquid. in 20 mM HEPES( pH 7.5) containing 1 mM DTT, 100 mM KCl2.
Purity: > 95% by SDS - PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
Sequences Of Amino Acids: MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR AM G GA VPFKA ALTERLALIQ PSREQVQRLI AEQPPHLTPGIRELVSRLQERNVQVF LI SG GFRSIVEHVA SKLNIPATNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK V I KLLKEKFH FKKIIMIGDGATDMEACPPA DAFIGFGGNV IRQQVKDNAK WY IT D F VELL GELEE.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PSPH phosphoserine phosphatase [ Homo sapiens ]
Synonyms: PSPH; phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrol ase; L-3-phosphoserine phosphatase; EC 3.1.3.3
Gene ID: 5723
mRNA Refseq: NM_004577
Protein Refseq: NP_004568
MIM: 172480
UniProt ID: P78330
Chromosome Location: 7p11.2
Pathway: Glycine, serine and threonine metabolism; Metabolic pathways
Function: hydrolase activity; magnesium ion binding; phosphoserine phosphatase activity; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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