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Recombinant Human Phosphoserine Phosphatase

Cat.No. : PSPH-198H
Product Overview : Recombinant human Phosphoserine Phosphatase was overexpressed inE. coliand purified by conventional chromatography. MW = 25 kDa (225 aa).
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Cat. No. : PSPH-198H
Description : Human Phosphoserine phosphatase (hPSP) is an important enzyme in the phosphorylated pathway of serine biosynthesis, which contributes a major portion of the endogenous L-serine. Similar to known L-3-phosphoserine phosphatases, it catalyzed the Mg2+-dependent hydrolysis of L-phosphoserine and an exchange reaction between L-serine and L-phosphoserine. Recently, its complex structures reveal that the open-closed environmental change of the active site, generated by local rearrangement of the -helical bundle domain, is important to substrate recognition and hydrolysis.
Source : Escherichia Coli.
Form : Liquid. in 20 mM HEPES( pH 7.5) containing 1 mM DTT, 100 mM KCl2.
Purity : > 95% by SDS - PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Endotoxin Level : < 1.0 EU per 1 μg of protein (determined by LAL method).
Sequences Of Amino Acids : MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR AM G GA VPFKA ALTERLALIQ PSREQVQRLI AEQPPHLTPGIRELVSRLQERNVQVF LI SG GFRSIVEHVA SKLNIPATNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK V I KLLKEKFH FKKIIMIGDGATDMEACPPA DAFIGFGGNV IRQQVKDNAK WY IT D F VELL GELEE.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PSPH phosphoserine phosphatase [ Homo sapiens ]
Synonyms : PSPH; phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrol ase; L-3-phosphoserine phosphatase; EC 3.1.3.3
Gene ID : 5723
mRNA Refseq : NM_004577
Protein Refseq : NP_004568
MIM : 172480
UniProt ID : P78330
Chromosome Location : 7p11.2
Pathway : Glycine, serine and threonine metabolism; Metabolic pathways
Function : hydrolase activity; magnesium ion binding; phosphoserine phosphatase activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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