Recombinant Human ACP5 protein(Met1-Pro320), His-tagged
Cat.No. : | ACP5-240H |
Product Overview : | Recombinant Human ACP5 (NP_001602.1)(Met 1-Pro 320) was expressed in HEK293 with a C-terminal polyhistidine tag. |
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Source : | HEK293 |
Species : | Human |
Tag : | C-His |
Protein length : | Met1-Pro320 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The secreted recombinant human ACP5 comprises 310 amino acids with a predicted molecular mass of 35 kDa as estimated by SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens ] |
Official Symbol : | ACP5 |
Synonyms : | ACP5; acid phosphatase 5, tartrate resistant; tartrate-resistant acid phosphatase type 5; tartrate resistant acid phosphatase; TRAP; TrATPase; tartrate-resistant acid ATPase; SPENCDI; |
Gene ID : | 54 |
mRNA Refseq : | NM_001111034 |
Protein Refseq : | NP_001104504 |
MIM : | 171640 |
UniProt ID : | P13686 |
Products Types
◆ Recombinant Protein | ||
ACP5-2416H | Recombinant Human ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACP5-43R | Recombinant Rhesus Macaque ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACP5-117R | Recombinant Rat ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Acp5-516M | Recombinant Mouse Acp5 Protein, MYC/DDK-tagged | +Inquiry |
ACP5-904H | Recombinant Human ACP5 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ACP5-2431MCL | Recombinant Mouse ACP5 cell lysate | +Inquiry |
ACP5-2809HCL | Recombinant Human ACP5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionthe loss of Acp5 significantly protected mice from BLM-induced lung injury and fibrosis, accompanied by a marked reduction in myofibroblast accumulation.
Alteplase, Filgrastim, and Streptozocin.
They are Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors; Vitamin B2 (riboflavin) metabolism
ACP5 promoted A549 and NCI-H1975 cells undergoing epithelial-mesenchymal transition (EMT) via P53/Smad3 signaling.
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Diseases associated with ACP5 include spondyloenchondrodysplasia with Immune dysregulation and Hairy Cell Leukemia. Among its related pathways are metabolism of water-soluble. vitamins and cofactors and Metabolism
Serum concentration of ACP5 was likely associated with decreased lung function in IPF patients.
Acp5 is upregulated by transforming growth factor-β1 (TGF-β1) in a TGF-β receptor 1 (TGFβR1)/Smad family member 3 (Smad3)-dependent manner, after which Acp5 dephosphorylates p-β-catenin at serine 33 and threonine 41, inhibiting the degradation of β-catenin and subsequently enhancing β-catenin signaling in the nucleus, which promotes the differentiation, proliferation and migration of fibroblast.
ACP5 is evaluated as osteoclast differentiation/activity markers in serum and in culture.
Acp5 deficiency protects mice from BLM-induced lung injury and fibrosis coupled with a significant reduction of fibroblast differentiation and proliferation.
Customer Reviews (5)
Write a reviewArrived prompt - good service
Much better than similar products that I've used.
Used in protein electron microscopy structure analysis.Great.
Great performance in WB :)
Patient customer service, love it.
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