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Recombinant Human ACP5 protein(Met1-Pro320), His-tagged

Cat.No. : ACP5-240H
Product Overview : Recombinant Human ACP5 (NP_001602.1)(Met 1-Pro 320) was expressed in HEK293 with a C-terminal polyhistidine tag.
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Source : HEK293
Species : Human
Tag : C-His
Protein length : Met1-Pro320
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The secreted recombinant human ACP5 comprises 310 amino acids with a predicted molecular mass of 35 kDa as estimated by SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens ]
Official Symbol : ACP5
Synonyms : ACP5; acid phosphatase 5, tartrate resistant; tartrate-resistant acid phosphatase type 5; tartrate resistant acid phosphatase; TRAP; TrATPase; tartrate-resistant acid ATPase; SPENCDI;
Gene ID : 54
mRNA Refseq : NM_001111034
Protein Refseq : NP_001104504
MIM : 171640
UniProt ID : P13686

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What will happen if loss ACP5 in vivo? 02/19/2022

the loss of Acp5 significantly protected mice from BLM-induced lung injury and fibrosis, accompanied by a marked reduction in myofibroblast accumulation.

Could please list three drugs for ACP5 gene? 09/26/2021

Alteplase, Filgrastim, and Streptozocin.

What are four reactome pathways for ACP5 gene? 06/11/2021

They are Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors; Vitamin B2 (riboflavin) metabolism

How does ACP5 epithelial-mesenchymal transition (EMT)? 01/31/2021

ACP5 promoted A549 and NCI-H1975 cells undergoing epithelial-mesenchymal transition (EMT) via P53/Smad3 signaling.

Can you briefly descibe the molecular function of ACP5 protein? 05/22/2020

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

How about the human health condition related to ACP5 gene changes? 05/20/2020

Diseases associated with ACP5 include spondyloenchondrodysplasia with Immune dysregulation and Hairy Cell Leukemia. Among its related pathways are metabolism of water-soluble. vitamins and cofactors and Metabolism

What is the effect of ACP5 serum concentration on Idiopathic pulmonary fibrosis (IPF) patients? 05/15/2019

Serum concentration of ACP5 was likely associated with decreased lung function in IPF patients.

What is the role of ACP5 on the process of fibroblast's cell differentiation and proliferation? 03/30/2019

Acp5 is upregulated by transforming growth factor-β1 (TGF-β1) in a TGF-β receptor 1 (TGFβR1)/Smad family member 3 (Smad3)-dependent manner, after which Acp5 dephosphorylates p-β-catenin at serine 33 and threonine 41, inhibiting the degradation of β-catenin and subsequently enhancing β-catenin signaling in the nucleus, which promotes the differentiation, proliferation and migration of fibroblast.

What functions does ACP5 could apply when we act it as biomarks? 08/03/2018

ACP5 is evaluated as osteoclast differentiation/activity markers in serum and in culture.

What will happen to mice if ACP5 deficiency present? 04/08/2018

Acp5 deficiency protects mice from BLM-induced lung injury and fibrosis coupled with a significant reduction of fibroblast differentiation and proliferation.

Customer Reviews (5)

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Reviews
08/03/2022

    Arrived prompt - good service

    09/11/2021

      Much better than similar products that I've used.

      07/02/2021

        Used in protein electron microscopy structure analysis.Great.

        01/10/2021

          Great performance in WB :)

          06/20/2018

            Patient customer service, love it.

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