Recombinant Human DPP4 protein
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|Product Overview :||Recombinant Human DPP4 (Asn29-Pro766) protein carried no tag and was expressed in human 293 cells (HEK293).|
|Description :||Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.|
|Predicted N Terminal :||Asn29|
|Form :||Lyophilized from 0.22 μm filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 85.4 kDa. The protein migrates as 95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Asn29-Pro766|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of DPP4-270H :||
Human DPPIV, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Comparison of the susceptibility of porcine and human dipeptidyl-peptidase IV to inhibition by protein-derived peptides (2015)
|Gene Name :||DPP4|
|Official Symbol :||DPP4|
|Synonyms :||DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2, CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); CD26; ADABP; ADCP2; TP103|
|Gene ID :||1803|
|mRNA Refseq :||NM_001935|
|Protein Refseq :||NP_001926|
|UniProt ID :||P27487|
◆ Recombinant Protein
|DPP4-2844H||Recombinant Human DPP4 Protein||+Inquiry|
|DPP4-2540H||Recombinant Human DPP4 Protein, MYC/DDK-tagged||+Inquiry|
|DPP4-2845H||Recombinant Human DPP4 Protein, GST-tagged||+Inquiry|
|Dpp4-2641M||Recombinant Mouse Dpp4 Protein, Myc/DDK-tagged||+Inquiry|
|DPP4-116H||Recombinant Human DPP4 Protein, His-tagged||+Inquiry|
◆ Native Protein
|DPP4-31H||Native Human DPP4||+Inquiry|
|DPP4-197H||Native Human Dipeptidyl Peptidase IV||+Inquiry|
|DPP4-2979HCL||Recombinant Human DPP4 cell lysate||+Inquiry|
|DPP4-733CCL||Recombinant Cynomolgus DPP4 cell lysate||+Inquiry|
◆ Assay kits
|Kit-0315||DPP4 Inhibitor Screening Kit||+Inquiry|
|Kit-0314||DPP4 Activity Fluorometric Assay Kit||+Inquiry|