"PDGFC" Related Products

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Recombinant Human PDGFC, Fc Chimera

Cat. No. : PDGFC-206H
Product Overview : Recombinant Human PDGF-C encoding the mature form of human PDGF-C (NP_057289.1) ( Val 235- Gly 345 ) was expressed with the fused Fc region of human IgG1 at the N-terminus. It was produced inHEK293.
Description : The human platelet-derived growth factor C (PDGF-C) is one of the four member of the PDGF family of growth factors which are known mitogens and survival factors for cells of mesenchymal origin. They form four disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and one heterodimer (PDGF-AB). PDGF-C has a unique two-domain structure consisting of an N-terminal CUB and a conserved C-terminal growth factor domain that are separated by a hinge region. PDGF-CC only binds to PDGF Rα with high affinity, activates the homodimerization of PDGF Rαβ, and induces the signal pathways, such as profibrotic pathways in hepatic fibrosis. PDGF-CC is involved in a variety of processes including angiogensis, morphogenesis and cardiovascular development, as well as the tumorigenesis.
Molecular Mass : The recombinant human PDGFC/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 348 amino acids and predicts a molecular mass of 39 KDa. As a result of glycosylation, rh PDGFC/Fc monomer is approximately 45KDa in SDS-PAGE under reducing conditions.
Source : Human Cells(HEK293).
Predicted N Terminal : Glu 20.
Purity : > 97%, as determined by SDS-PAGE.
Formulation : Supplied as a 0.2μm filtered solution of 100mM Glycine, 10mM NaCl,50mM Tris, pH7.5.
Endotoxin : < 1.0 EU per 1μg cytokine as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt -70°C.
Reconstitution : Follow the instructions on the vial. Centrifuge the vial at 4°C before opening to recover the entire contents.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Pathways : Cytokine-cytokine receptor interaction; Regulation of actin cytoskeleton; Focal adhesion; Gap junction; Melanoma; Prostate cancer; Signaling by PDGF; Signaling by VEGF
Gene Name : PDGFC platelet derived growth factor C [ Homo sapiens ]
Synonyms : platelet derived growth factor C; SCDGF; FALLOTEIN; PDGFC; spinal cord-derived growth factor; secretory growth factor-like protein; fallotein; fallotein; PDGF-C; VEGF-E; Spinal cord-derived growth factor; platelet-derived growth factor C
Gene ID : 56034
mRNA Refseq : NM_016205
Protein Refseq : NP_057289
MIM : 608452
UniProt ID : Q9NRA1
Chromosome Location : 4q32
Function : platelet-derived growth factor receptor binding; protein homodimerization activity; growth factor activity; cell surface binding

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