Recombinant Mouse Scavenger Receptor Class B, Member 1, Fc-His


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Recombinant Mouse Scavenger Receptor Class B, Member 1, Fc-His

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Cat. No. : Scarb1-847M
Product Overview : Recombinant Mouse Scarb1 encoding the human SCARB1 (NP_005496.4) extracellular domain (Pro 33- Tyr 443) was fused with the C-terminal his-tagged Fc region of human IgG1 at the C-terminus. It was produced inHEK293.
Description : Scavenger receptor class B, member 1, also known as SCARB1, SRB1 and CD36L1,is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non-placental steroidogenic tissues. It binds high density lipoproteins (LDL) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 is a key component in the reverse cholesterol transport pathway and plays an important role in lipid metabolism. Accordingly, SCARB1 may serve as a useful marker that predicts variation in baseline lipid levels, postprandial lipid response, and response to fenofibrate intervention. The human CD36 and LIMPII analogous-1 (CLA-1) receptor shows high sequence homology with SCARB1, but their functional relationship has not been determined.
Molecular Mass : The recombinant human SCARB1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 659 amino acids and has a predicted molecular mass of 78 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSCARB1/Fc monomer is approximately 110-115 kDa due to glycosylation.
Source : Human Cells (HEK293).
Predicted N Terminal : Pro 33.
Endotoxin : < 1.0 EU per 1μg cytokine as determined by the LAL method.
Formulation : Supplied as a 0.2μm filtered solution of PBS, pH7.4.
Reconstitution : Follow the instructions on the vial. Centrifuge the vial at 4°Cbefore opening to recover the entire contents.
Purity : > 98%, as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt -70°C.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Gene Name : Scarb1 scavenger receptor class B, member 1 [ Mus musculus ]
Synonyms : Scarb1; scavenger receptor class B, member 1; CD36; Cla1; SRBI; Srb1; Cla-1; SR-B1; SR-BI; Cd36l1; Hlb398; mSR-BI; AI120173; D5Ertd460e; OTTMUSP00000026063; scavenger receptor class B1; scavenger receptor class B type I
Gene ID : 20778
mRNA Refseq : NM_016741
Protein Refseq : NP_058021
UniProt ID : Q61009
Chromosome Location : 68.0 cM
Function : high-density lipoprotein binding; receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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