Mitotic checkpoint serine/threonine-protein kinase BUB1

• Cat.No.: CBCRY01

Specification

• Cat. No.: CBCRY01
• Background: The kinase(BUB1) functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
• Protein Classification: Transferase
• Structure Weight: 42450.29 Da
• Polymer: 1
• Molecule: Mitotic checkpoint serine/threonine-protein kinase BUB1
• Chain Length: 365 amino acids
• PDB ID: 3E7E
• MMDB ID: 68144
• Source: Spodoptera frugiperda
• Method: X-Ray Diffraction
• Resolution: 2.31Å
• Ligand Chemical Component: Adenosine-5"-triphosphate; chloride ion; Magnesium ion
• Reference: Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.Mol Cell. 2008 Nov 7;32(3):394-405.

Gene Information

• Gene Name: BUB1
• Synonyms: BUB1A, BUB1L, hBUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
• UniProt ID: O43683
• Gene ID: 699
• Chromosome Location: 2q14
• Function: nucleotide binding; protein kinase activity; protein serine/threonine kinase activity ; ATP binding; kinase activity; transferase activity