Mitotic checkpoint serine/threonine-protein kinase BUB1 CBCRY01

Mitotic checkpoint serine/threonine-protein kinase BUB1

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Mitotic checkpoint serine/threonine-protein kinase BUB1

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Cat. No. : CBCRY01
Background : The kinase(BUB1) functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
Protein Classification : Transferase
Structure Weight : 42450.29 Da
Polymer : 1
Molecule : Mitotic checkpoint serine/threonine-protein kinase BUB1
Chain Length : 365 amino acids
PDB ID : 3E7E
MMDB ID : 68144
Source : Spodoptera frugiperda
Method : X-Ray Diffraction
Resolution : 2.31Å
Ligand Chemical Component : Adenosine-5"-triphosphate; chloride ion; Magnesium ion
Reference : Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.Mol Cell. 2008 Nov 7;32(3):394-405.
Gene Name : BUB1
Synonyms : BUB1A, BUB1L, hBUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
UniProt ID : O43683
Gene ID : 699
Chromosome Location : 2q14
Function : nucleotide binding; protein kinase activity; protein serine/threonine kinase activity ; ATP binding; kinase activity; transferase activity

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