"MAD2" Related Products

Mitotic arrest deficient 2

Cat. No.: CBCRY02
Background: MAD2 (mitotic arrest deficient 2) is one of the kinetochore protein present on the chromosome during cell division. It is involved in making sure all chromosomes are attached to the mitotic spindle before the beginning of anaphase.
Protein Classification: Cell Cycle
Structure Weight: 288687.00 Da
Polymer: 1
Molecule: Mitotic Spindle assembly checkpoint protein MAD2A
Chain Length: 206 amino acids
PDB ID: 2VFX
MMDB ID: 63130
Source: E.coli
Method: X-Ray Diffraction
Resolution: 1.95 Å
Ligand Chemical Component: Chloride ion, Magnesium ion, PE3, PE4, PEG
Reference: Yang, M., Li, B., Liu, C.-J., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. (2008) Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer. Plos Biol. 6: E50
Gene Name: MAD2L1
Synonyms: HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1
UniProt ID: Q13257
Gene ID: 4085
Chromosome Location: 4q27
Function: protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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