Recombinant Human Centromere Protein A, His-tagged CENPA-617H

Recombinant Human Centromere Protein A, His-tagged


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Recombinant Human Centromere Protein A, His-tagged

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Cat. No. : CENPA -617H
Product Overview : Recombinant Human CENP-A produced inSF9is a glycosylated, polypeptide chain having a molecular mass of 17,015 Dalton. CENP-A is expressed with a -6x His tag and purified by proprietary chromatographic techniques
Description : Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. Currently, 9 centromere proteins are known and designated CENP-A to CENP-I. Most of the centromere proteins are targets of autoantibodies, the anti-centromere antibodies. CENP-A is another important centromeric autoantigen in addition to CENP-B: it has a molecular weight of approx. 20 kDa and is incorporated into centromeric chromatin due to its histone-like properties. CENP-A antibodies are an important marker for correct diagnosis of Scleroderma / CREST syndrome in CENP-B-autoantibody negative patients.
Source : Sf9 insect cells.
Physical Appearance : Sterile Filtered liquid formulation.
Formulation : CENP-A is supplied at a concentration of 0.6 mg/ml in 20mM HEPES buffer pH-8, 100mM sodium chloride, and 6M Urea.
Immunological Functions : Binds IgG-type human auto-antibodies.Standard ELISA test (checker-board analysis of positive/negative sera panels including CDC international reference sera).
Applications : Western-Blot with monoclonal anti-hexa-His-tag antibody & Scleroderma patient sera.
Purity : Greater than 90% as determined by SDS-PAGE.
Coating Concentration : 0.15-0.4 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.
Storage Conditions : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name : CENPA centromere protein A [ Homo sapiens ]
Synonyms : centromere protein A; CENP-A; CENPA; centromere protein A, 17kDa; centromere protein A (17kD); OTTHUMP00000122589; Centromere autoantigen A
Gene ID : 1058
mRNA Refseq : NM_001042426
Protein Refseq : NP_001035891
MIM : 117139
UniProt ID : P49450
Chromosome Location : 2p24-p21
Pathway : Cell Cycle, Mitotic
Function : DNA binding; chromatin binding; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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