Extracellular fragment of Fc alpha Receptor I (CD89) CBCRY06

Extracellular fragment of Fc alpha Receptor I (CD89)


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Extracellular fragment of Fc alpha Receptor I (CD89)

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Cat. No. : CBCRY06
Background : Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs.
Protein Classification : Immune System
Structure Weight : 25006.40 Da
Polymer : 1
Molecule : Immunoglobulin alpha Fc receptor
Chain Length : 218 amino acids
MMDB ID : 24338
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.1Å
Reference : Ding, Y., Xu, G., Yang, M., Yao, M., Gao, G.F., Zhang, W., Rao, Z. Crystal Structure of the Ectodomain of Human Fc{alpha}RI.J.Biol.Chem. 2003;278: 27966-27970
Gene Name : FCAR
Synonyms : XXbac-BPG230H20.5, CD89; Fc alpha receptor; IgA Fc receptor; OTTHUMP00000068692; OTTHUMP00000068696; OTTHUMP00000068697; OTTHUMP00000068698; CD89; CD89 antigen; Fc receptor; Fc fragment of IgA, receptor; IgA Fc receptor
UniProt ID : P24071
Gene ID : 2204
Chromosome Location : 19q13.2-q13.4
Function : IgA binding; receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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