"TNFSF9" Related Products


Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 9

Cat. No.: TNFSF9-924H
Product Overview: Recombinant human 4-1BBL produced inE.coliis a soluble 19.5 kDa protein consisting of 185 amino acid residues.
Description: 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL.
Source: E.coli.
Purity: > 98% by SDS-PAGE and HPLC analyses.
Endotoxin level: < 0.1 ng per μg of 4-1BBL.
Stabilizer: None.
Formulation: Lyophilized.
Biologically Activity: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The expected ED50 for this effect is 5-10 ng/ml. Results may vary with different PBMC donors.
Reconstitution: Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted human 4-1BBL is stable for at least 3 months when stored in working aliquots with carrier protein at -20°C. Avoid repeated freeze-thaw cycles.
Gene Name: TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 [ Homo sapiens ]
Synonyms: TNFSF9; tumor necrosis factor (ligand) superfamily, member 9; CD137L; 4-1BB-L; TNFSF9; tumor necrosis factor (ligand) superfamily, member 9;receptor 4-1BB ligand; homolog of mouse 4-1BB-L; 4-1BBL; 4-1BB ligand; receptor 4-1BB ligand
Gene ID: 8744
mRNA Refseq: NM_003811
Protein Refseq: NP_003802
MIM: 606182
UniProt ID: P41273
Chromosome Location: 19p13.3
Pathway: Cytokine-cytokine receptor interaction
Function: cytokine activity; tumor necrosis factor receptor binding

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