"IDI1" Related Products

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Isopentenyl-diphosphate delta-isomerase 1

Cat. No.: CBCRY10
Background: IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
Protein Classification: Isomerase
Structure Weight: 56107.39 Da
Polymer: 1
Molecule: Isopentenyl-diphosphate delta-isomerase 1
Chain Length: 255 amino acids
PDB ID: 2I6K
MMDB ID: 46256
Source: E.coli
Method: X-Ray Diffraction
Resolution: 2.00?
Ligand Chemical Component: Acetic acid; Aminoethanolpyrophosphate; Magnesium ion; Manganese ion
Reference: Zhang, C., Liu, L., Xu, H., Wei, Z., Wang, Y., Lin, Y., Gong, W.(2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanismJ.Mol.Biol.366: 1437-1446
Gene Name: IDI1
Synonyms: IPP1; IPPI1; EC 5.5.5.2; IPP isomerase; IPP isomerase; OTTHUMP00000018951; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate delta isomerase
UniProt ID: Q13907
Gene ID: 3422
Chromosome Location: 10p15.3
Function: magnesium ion binding; isopentenyl-diphosphate delta-isomerase activity; hydrolase activity; isomerase activity; metal ion binding

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